Conformational Dynamics of a “Titratable” Cardiac Inotrope
نویسندگان
چکیده
منابع مشابه
Vasopressor stays vasopressor and inotrope stays inotrope!
We should like to comment on the interesting work reported by Müller and colleagues [1]. We feel that the results of their experiment were predictable and that arginine vasopressin (AVP) was not indicated in that setting. Infusing a vasoconstrictor without relevant inotropic potential in an acute low flow state with maintained or increased vascular tone must further augment organ vascular resis...
متن کاملConformational dynamics of vesicles.
The transport of ions and molecules through membranes is a key ingredient to many biophysical processes. For example, contemporary attempts for gene therapy require transport of DNA fragments through the cellular and nuclear membranes (1); signaling depends on ionic transport through dynamic pores in membranes (see, for example, ref. 2); efficient drug delivery vehicles based on vesicular ‘‘bag...
متن کاملConformational Dynamics of Insulin
We have exploited a prandial insulin analog to elucidate the underlying structure and dynamics of insulin as a monomer in solution. A model was provided by insulin lispro (the active component of Humalog(®); Eli Lilly and Co.). Whereas NMR-based modeling recapitulated structural relationships of insulin crystals (T-state protomers), dynamic anomalies were revealed by amide-proton exchange kinet...
متن کاملConformational dynamics data bank: a database for conformational dynamics of proteins and supramolecular protein assemblies
The conformational dynamics data bank (CDDB, http://www.cdyn.org) is a database that aims to provide comprehensive results on the conformational dynamics of high molecular weight proteins and protein assemblies. Analysis is performed using a recently introduced coarse-grained computational approach that is applied to the majority of structures present in the electron microscopy data bank (EMDB)...
متن کاملGenerative models of conformational dynamics.
Atomistic simulations of the conformational dynamics of proteins can be performed using either Molecular Dynamics or Monte Carlo procedures. The ensembles of three-dimensional structures produced during simulation can be analyzed in a number of ways to elucidate the thermodynamic and kinetic properties of the system. The goal of this chapter is to review both traditional and emerging methods fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.871